iGEM Team's Journey to Silver

Sixteen BBSG Secondary students came together to form the school's first iGEM team, united by a fascination with science. Like a finely tuned research unit, each member contributed their strengths—conducting laboratory experiments, engaging with experts and communities, producing videos and building the team website to share their findings.

Guided by their Principal Investigator and advisors, the team completed the full research cycle: project conception, scientific investigation, experimental validation, and public engagement. Their dedication and innovative approach earned a Silver Medal at the 2025 iGEM Competition.

Healing Fish Hearts with 

Leech Medicine

Cardiovascular disease is the leading cause of death in humans—but fish can suffer too. In aquaculture, many fish die from blood clots, yet the cause often goes undetected. The team focused on hirudin, a natural anticoagulant produced by leeches and historically used to treat human cardiovascular disease. They asked: could it also protect fish hearts?

Wet Lab Experiments

Hirudin genes from twelve leech species were identified and synthesised for study. Using fluorescent protein as a marker, the team tested the antithrombotic effects of each variant in fish blood. This enabled them to identify the most effective molecule, paving the way for interventions to improve fish welfare and reduce mortality in aquaculture.

LB plates showing successful transformation

Colony PCR confirming positive clones

By combining biology, medicine, and animal care, the project demonstrates a sustainable "nature solving nature" approach, exploring fundamental science while addressing a real-world problem.

Science Beyond the Laboratory

Their work extended far beyond the laboratory. Over a year-long Integrated Humanity Practices Journey, the iGEM team transformed an initial concept into a responsible, real-world initiative. 

Engagements with experts and first-hand experiences in diverse environments not only enriched their understanding of science, ethics, and societal impact but also provided crucial feedback to shape and refine their project:

• Integrated Human Practices journey 

Attending the International Genomics Conference at BGI: gained inspiration from leading scientists and pioneering research projects.

Visiting HKUST (GZ): acquired practical insights into iGEM project design, laboratory techniques, and effective project management from experienced teams.

Attending a Lecture by Dr. Tian Fang: explored the symptoms, risk factors, and prevention of cardiovascular disease in humans.

Visiting Guangdong University of Chinese Medicine: examined how heart attack and stroke are approached in traditional Chinese medicine.

Visiting Mosquito and Fish Farms: investigated natural anticoagulants and observed aquaculture practices firsthand, connecting laboratory research to real-world applications.

Workshops with Leading Scientists: Dr. Jijie Chai and Dr. Zhao Bingran shared their research journeys, inspiring scientific curiosity and a commitment to societal impact.

Science Communication Training: Toastmasters sessions enhanced the team's ability to convey complex science to diverse audiences.

Through these experiences, the team discovered that science flourishes at the intersection of curiosity, collaboration, and social responsibility. Engagements with experts and communities provided valuable insights and feedback that helped the team continuously refine and strengthen their project.

At the end of the journey, we came to a vital realisation. Through interacting with other people, we gained a lot of scientific knowledge. But this project isn't just about science—the human spirit holds the greatest significance. Inspired by the quality of the scientists, we understood the passion, perseverance, and commitment they've devoted to science.

—— iGEM Team

A Year of Growth and Discovery

The iGEM journey transformed the students. Beyond biology, they developed research, teamwork, communication, and project management skills, while cultivating resilience, creativity, and scientific thinking. Every challenge—from laboratory experiments to public engagement—became an opportunity to learn and grow, as shared by Dr. Gert Grobler, Principal Investigator of the iGEM team.

As the project drew to a close, the iGEM team had evolved from curious learners into confident leaders. Through the "Gopher Science Labs" in collaboration with the Royal Society of Biology, members designed and delivered biology lessons to primary school students, sharing their knowledge, igniting curiosity, and passing on their passion for science.

The iGEM team's journey illustrates that scientific discovery is not just about experiments or data—it is about growth, leadership, and impact. They have learned to translate curiosity into action, knowledge into teaching, and passion into solutions that make a meaningful difference, leaving a lasting mark on both their community and the wider world.

The next iGEM project is launching in collaboration with Benenden UK!

The two schools have already held online meetings to brainstorm a project that excites students on both sides. Over the coming year, they will approach real-world challenges through a global lens, combining curiosity, creativity, and hands-on research. A new year of discoveries and surprises awaits—stay tuned!